Turnkey Granulation Line Solutions
☑ 20+ years of granulation line expertise
☑ Tailored modern granulation line solutions
☑ Optimized for batch consistency
☑ Wet and dry granulation lines available
☑ Customized to your factory layout
☑ Compliant with international regulatory standards
Multi-Industry Granulation Lines
We specialize in pharmaceutical granulation lines designed to produce tablets and other solid dosage drugs. Our solutions are also essential in other industries like cosmetics, food, chemicals, and nutraceuticals. They’re an integral part of processing products like supplements, veterinary medications, and sugar.
What Is A Granulation Line?
A granulation line refers to a collection of machines and equipment that works together to turn raw powder into granules. This process is called granulation. During granulation, SaintyCo machinery ensures consistent particle size which improves the flow properties of the material. This leads to better handling downstream at tableting or encapsulation stations.
Our granulation lines can have slightly different setups depending on the application. But generally speaking, they’re made up of the following stages: mixing, wet or dry granulation, drying, milling, and final blending.
SaintyCo granulation lines are engineered for diverse industries and use cases. For example, clients use SaintyCo lines to granulate everything from gravy to highly potent active pharmaceutical ingredients (HPAPIs) like estrogen or digoxin.
Types Of Granulation Line
We manufacture granulation lines that fall into several key categories. Within each category, our machinery can be further configured to meet your specific needs.
Uses liquid binders to agglomerate powders for better flow with minimal dust generation.
Ideal for processing moisture or heat-sensitive powders quickly and effectively.
A top-to-bottom flow leverages gravity for optimized material processing and easier CIP.
A typical setup includes machinery stages adjacent to one another for a left-to-right flow.
For OEB 4/5 applications, built with restricted access barrier systems (RABS),
Sprays a binder solution onto a bed of powder fluidized by air blasts from underneath.
Mixes materials at a lower, more gentle speed, ideal for creating porous granules.
High-speed impeller creates intense mixing action to produce more dense granules.
Granulation Lines That Scale With You
At SaintyCo, we understand that your production needs change as your company grows or you take on new formulations. So, we’ve got a granulation line for every phase, from research to mass-production.
Compact lines that mirror full production setups for research, development, and pilot trials.
Our mid-range models are scalable, helping you increase capacity without a total line overhaul.
Our fully integrated, high-speed lines are engineered for large-scale and mass production.
Ask us about a tailored solution engineered specifically for your factory.
Benefits Of SaintyCo Granulation Lines
Our granulation lines are engineered for precision, scalability, and GMP compliance, whether your goal is simple batch processing or a complex integrated solution for continuous production.
Our power-saving technology keeps costs down.
Modular designs make it easier to scale.
Semi and fully-automated options.
Meets strict standards of cGMP, GMP, and FDA.
Intuitive, simple, and easy-to-navigate HMI.
Purposefully designed for user experience.
Take up minimal floor space in your factory or lab.
Built for durability with a long operational lifespan.
Key Stages Of A Granulation Line
Here at SaintyCo, we’re extremely flexible and can configure the perfect granulation line especially for your application. This is a breakdown of the core components our typical lines.
We offer manual powder loading systems for small-batch production or automatic vacuum feeders for high-volume lines. APIs and excipients are pre-mixed in a blender.
Either using a binder for wet granulation or roller compaction for dry, the powder is transformed into uniform granules. Twin-screw can be used for both types.
To reduce granules to consistent sizes, wet particles pass through an oscillating or cone mill. Dry flakes also known as ribbons are crushed.
This step is only applicable to wet granulation lines, where moisture must be removed from granules to ensure their stability. This involves precise temperature control.
When dry, our milling modules break down granules into their final particle size, often using a sieve mill or a dry cone mill with integrated dust extraction.
If necessary, active granules can be blended with lubricants or disintegrants at this stage in our V-blender, bin, or double-cone modules before being discharged to the next station.
Top Vs. Bottom Spray
For lines that use fluid bed granulation, we offer both top and bottom spray methods. Our top spray systems are the most commonly used, where a binder is sprayed from above. The bottom spray method is also called Wurster coating. This is frequently used for applying coatings to pellets or particles.
Validated CIP Cleaning
All SaintyCo granulation lines adhere to strict hygiene standards as set out by international and industry bodies. Our systems are designed for CIP, WIP, and SIP integration, depending on your needs, with full validation support. Features include self-draining piping, pharma-grade stainless steel contact surfaces, and innovative vertical workflows to optimize cleaning efforts.
More Resources
If you’re interested in seeing the full range of granulation lines from SaintyCo, please download this PDF version of our brochure.
Determine which granulation line is right for your production needs with this helpful data sheet that details technical parameters.
Have a look at an example of a SaintyCo granulation line in action as it turns fine powder into better-flowing granules at our China premises.
Your Leading Granulation Line Manufacturer
Whether you need a granulation line for a new building, or a system that can be integrated into your existing setup, we’re well equipped to help.
Here at SaintyCo, we’ve designed and fabricated thousands of diverse granulation lines for hundreds of clients globally. And now, we’re ready to make your project a success. Get in touch today to find out more about our exceptional engineering, reasonable pricing, and award-winning service.
More SaintyCo Granulation Lines
Shop some of the most recently ordered types of granulation solutions from SaintyCo, from batch-to-batch options through to non-stop production lines.
We manufacture top quality granulation lines that support intermittent granulation cycles. You can easily swap recipes between runs which makes it a flexible and convenient choice for pilot-scale operations or multi-prodict lines.
Our integrated, closed-loop systems are mainly used for producing high-potency API and solvent-based granules. They process media in a fully enclosed circuit to reduce loss and airborne particles and keep workers safe.
When you need high-speed, uninterrupted throughput, a SaintyCo continuous granulation line is the perfect choice. It offers complete automation and unbeatable consistency across long production runs.
SaintyCo granulation lines can be custom-configured using standardized units. So, you can add or remove components like fluid bed dryers, wet mills, and so on to meet evolving production needs (or constraints).
Get Full Control Over The Granulation Process
Choose the right level of automation for your granulation line to match your production aims, material properties, budget, and how much control you want over every element of the process.
If you’re running a small or medium-scale facility or are restrained by budget, our partially-automated granulation lines offer many advantages.
They automated certain steps like granule drying or mixing, while still allowing manual worker intervention for other stages like feeding or discharge.
Our high-end, fully-automated granulation lines incorporate advanced technology with cutting-edge machinery. The result is a fast and efficient workflow with centralized control (via PLC or SCADA).
It’s ideal for mass production and 24/7 processing with minimal supervision. It also reduces the risk of human error.
More About Our Granulation Lines
Learn more about the average performance parameters for our various capacity lines and view images of recently installed projects.
- Data Sheet
- After-Sales Service
| Small-Scale | Medium-Scale | Large-Scale | |
| Output Capacity | Up to 200 kg/h | Up to 500 kg/h | Up to 2,500 kg/h |
| Impeller Power | 5-15 kW | 15-37 kW | Up to 132 kW |
| Granule Chopper Power | ~2 kW | 5-11 kW | 40 kW |
| Chopper Speed | 1,500-2,800 rpm | 1,600-2,800 rpm | 1,500-2,800 rpm |
| Granule Size | 100-2,000 μm | 100-2,000 μm | 100-2,000 μm |
| Mixer Volume | 10-80 L | 100-600 L | 300-2,000 L |
| Mixer Speed | 140-500 rpm | 100-200 rpm | 120-200+ rpm |
| Cleaning | Manual or WIP | WIP or CIP | CIP/SIP compatible |
| Footprint | ~5m² | ~12m² | ~25m² |
| Control System | Basic PLC | PLC + HMI with data logging | PLC + SCADA |
We’re well-known throughout the industry for our fantastic after-sales service, which is available to you for the entire lifetime of your granulation line. So, if you need guidance on maintenance or trouble-shooting, you can rely on us even years into the future.
Your granulation line comes with a 12-month warranty as standard, but we’re on hand forever if you need spare parts, upgrades, or you want to swap out modules to scale up or down. We guarantee fast response times and unparalleled knowledge that can help you achieve the best possible production outcomes.
“We began making systematic upgrades to our production line last year, starting with the granulation line. Working with SaintyCo has been a breeze. Their standardized machinery was incredibly easy to integrate to our workflow. We were so impressed with their dry granulation solution that we’ve since upgraded the rest of our line to SaintyCo as well. We look forward to many, many more years working with SaintyCo in this successful partnership.”
Felix OttersteinCOO, Optekk“SaintyCo’s granulation line is everything we needed. As QA lead I deal with compliance and traceability has been a problem with our previous set up. We’ve gone from handwritten logs and backups to a single source SCADA system which pulls batch data, performance logs, trends etc automatically. Our company just underwent an audit in March and the new granulation line enabled us to meet their data requests more easily than ever before.”
Shivani PandyaTooling & Equipment Buyer, Wholesale Brand
Yes, SaintyCo is dedicated to providing full validation support including documentation for DQ, IQ, and OQ and FAT and SAT. We provide everything you need with your order and have a comprehensive after-sales service should you have any questions.
We’ve engineered every element of our granulation lines in a way that makes them not just easy to use, but also easy to install. We provide a detailed installation guide and technical manual with your order. We can provide on-site support if needed. Our technicians are also available by phone or email.
Yes! We have decades of experience developing custom granulation lines, from innovative vertical setups spanning multiple stories to creative space-saving solutions for small laboratories. To discuss your needs with our talented engineers, please send us your details using the online form.
Our Related Products
Vacuum FeederCommonly used for feeding powder into the granulating line.
Powder Filling LineAn alternative to granulation, powder can be filled directly.
Bottle Filling LineBottle filling happens downstream from granulation.
Pharmaceutical Roller CompactorAn essential part of our dry granulation lines.
Binder Delivery And Spray Nozzles
How binders are delivered can directly affect the granule uniformity and drying time. It can also change how well the granules are able to be compressed at downstream tablet pressing stations. SaintyCo uses precision-engineered spray nozzles to make sure binders are distributed evenly, regardless of the particular formulation.
You can choose between pneumatic atomizing nozzles (good for finer droplets) or hydraulic spray nozzles (recommended for thicker binder solutions). Our smart systems allow droplet size control, which you can adjust to match the absorption rate of your excipients. This is essential to avoid overwetting.
We also offer full control over spray timing, with pulse-based or mass flow-controlled options. Our granulation lines also feature anti drip valves and clog resistant nozzle designs to make cleaning easier, extend machinery lifetime, and reduce maintenance and downtime. For GMP compliance, our spray modules also include calibrated flow meters as well as validation-ready control logs and repeatable dosing sequences.
Granulation Line Safety Systems
Every component, module, and machine in SaintyCo granulation lines is engineered with the very latest safety features and according to the strictest standards. This built-in safety logic protects both operators and equipment. Each unit includes interlocked access panels which prevents the lid/bowl being opened during cycles where it would be dangerous to do so.
There are multiple emergency stop buttons at various points, depending on the granulation line configuration. They trigger immediate power-down, and you can enable programmable soft-stop modes to prevent batch damage during mid-cycle shutdowns too.
Motors, pumps, and spray lines are monitored by overload sensors. If thresholds are exceeded (whether it’s pressure, vibration, temperature, or current) then the machine shuts down and triggers a diagnostic alert via the HMI. You can also investigate shut downs via the PLC logs which provide audit trails, access restrictions, batch records, and more for 21 CFR Part 11-compliance.
We offer several types of blender integrated to our granulation lines. For example, double-cone, conta-piller, octagonal, and V-style blenders.
Our granulation lines use a closed system to transfer materials, with dust-free charging and discharging thanks to vacuum feeders.
A granulation line can cost almost as much or as little as you want it to, depending on the spec. If you’d like a quote for your desired granulation line setup, please contact us directly.
It begins with mixing APIs and excipients to make a homogenous powder, before being compacted in dry granulation or kneaded with the help of a binder in wet granulation. Then comes drying (if wet granulation) followed by sizing via milling or screening, and final blending before discharge.
SaintyCo granulation lines are used across multiple industries, primarily the pharmaceutical industry but also food, nutraceutical, chemical manufacturing.